sammielynn-according to the sh page you can take one once a day so i am guessing that that means anytime (not strict like amp that is on a 24 hour clock) during the day. as it does not follow any kind of time schedule u should be able to take 1 at night and then again the next day (this is my own personal opinion so if i am wrong maybe someone else could chime in). so sorry that your sh did not credit. HTH.